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Read article at publisher's site DOI : Front Immunol , , 28 Aug Radiol Oncol , 53 1 , 03 Mar PLoS One , 13 7 :e, 17 Jul Cancer Immunol Immunother , 67 12 , 10 May Cited by 3 articles PMID: Front Immunol , , 13 Nov This data has been text mined from the article, or deposited into data resources. This data has been provided by curated databases and other sources that have cited the article.

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Affiliations All authors 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook. The lymphocytes of cathepsin C-null mice are therefore proposed to totally lack granzyme B activity and perforin-dependent cytotoxicity. The cathepsin C-null CTL expressed reduced but still appreciable granzyme B activity, but minimal granzyme A activity. Overall, our results indicate that although cathepsin C clearly generates the majority of granzyme B activity, some is still generated in its absence, pointing to alternative mechanisms for granzyme B processing and activation.

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Increased cystatin F levels correlate with decreased cytotoxicity of cytotoxic T cells. Cystatin F as a regulator of immune cell cytotoxicity. Data that cites the article This data has been provided by curated databases and other sources that have cited the article. Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. Granzyme C supports efficient CTL-mediated killing late in primary alloimmune responses.

Expression of multiple granzymes by cytotoxic T lymphocyte implies that they activate diverse apoptotic pathways in target cells. Orphan granzymes find a home. This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

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Nature of Privatization in Latin America

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Cathepsin C activates serine proteases expressed in hematopoietic cells by cleaving an N-terminal dipeptide from the proenzyme upon granule packaging. The lymphocytes of cathepsin C—null mice are therefore proposed to totally lack granzyme B activity and perforin-dependent cytotoxicity. The cathepsin C—null CTL expressed reduced but still appreciable granzyme B activity, but minimal granzyme A activity. Overall, our results indicate that although cathepsin C clearly generates the majority of granzyme B activity, some is still generated in its absence, pointing to alternative mechanisms for granzyme B processing and activation. The granzymes, a family of structurally related serine proteases expressed in cytotoxic lymphocytes, cooperatively bring about the death of transformed and virus-infected cells after their cosecretion with perforin Trapani and Smyth, Perforin is critical for permitting the access of granzymes and other granule-bound toxins to their substrates within the target cell Froelich et al. By comparison, deficiency of an individual granzyme is better tolerated by gene-targeted mice.

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