Metronidazole is in It works by stopping the growth of bacteria. Antibiotics will not work for colds, flu, or Metronidazole Vaginal. Metronidazole is in a class of medications called nitroimidazole antimicrobials.
|Published (Last):||3 September 2011|
|PDF File Size:||7.43 Mb|
|ePub File Size:||15.17 Mb|
|Price:||Free* [*Free Regsitration Required]|
Several pharmaceutical agents produce ethanol intolerance, which is often depicted as disulfiram-like reaction. As in the case with disulfiram, the underlying mechanism is believed to be the accumulation of acetaldehyde in the blood, due to inhibition of the hepatic aldehyde dehydrogenases. In the present study, chloramphenicol, furazolidone, metronidazole, and quinacrine, which are reported to produce a disulfiram-like reaction, as well as disulfiram, were administered to Wistar rats and the hepatic activities of alcohol and aldehyde dehydrogenases 1A1 and 2 were determined.
The expression of aldehyde dehydrogenase 2 was further assessed by Western blot analysis, while the levels of brain monoamines were also analyzed. Finally, blood acetaldehyde was evaluated after ethanol administration in rats pretreated with disulfiram, chloramphenicol, or quinacrine. The activity of aldehyde dehydrogenase 2 was inhibited by disulfiram, chloramphenicol, and furazolidone, but not by metronidazole or quinacrine.
In addition, although well known for metronidazole, quinacrine also did not increase blood acetaldehyde after ethanol administration. The protein expression of aldehyde dehydrogenase 2 was not affected at all. Interestingly, all substances used, except disulfiram, increased the levels of brain serotonin. According to our findings, metronidazole and quinacrine do not produce a typical disulfiram-like reaction, because they do not inhibit hepatic aldehyde dehydrogenase nor increase blood acetaldehyde.
Moreover, all tested agents share the common property to enhance brain serotonin, whereas a respective effect of ethanol is well established. Therefore, the ethanol intolerance produced by these agents, either aldehyde dehydrogenase is inhibited or not, could be the result of a "toxic serotonin syndrome," as in the case of the concomitant use of serotonin-active medications.
Name your collection: Name must be less than characters. Choose a collection: Unable to load your collection due to an error Please try again.
Add Cancel. Add to My Bibliography My Bibliography. Unable to load your delegates due to an error Please try again. Your saved search Name of saved search:.
Search terms:. Test search terms. Would you like email updates of new search results? Email: change. Frequency: Monthly Weekly Daily. Which day? Send at most: 1 item 5 items 10 items 20 items 50 items items items.
Send even when there aren't any new results. Optional text in email:. Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites. Abstract Several pharmaceutical agents produce ethanol intolerance, which is often depicted as disulfiram-like reaction.
Similar articles Differentiation of disulfiram effects on central catecholamines and hepatic ethanol metabolism. Karamanakos PN, et al. Pharmacol Toxicol. PMID: Metronidazole increases intracolonic but not peripheral blood acetaldehyde in chronic ethanol-treated rats.
Tillonen J, et al. Alcohol Clin Exp Res. Int J Toxicol. Epub Apr Jelski W, Szmitkowski M. Jelski W, et al. Clin Chim Acta. Epub May 8. PMID: Review. Susceptibility to alcohol-related liver injury. Lieber CS. Alcohol Alcohol Suppl. Show more similar articles See all similar articles. Infect Immun. Print Jan Alonzo MM, et al. J Pediatr Pharmacol Ther. Lieberman A, Curtis L. Lieberman A, et al. Drug Saf Case Rep.
Case Rep Neurol. Hennessey KM, et al. Show more "Cited by" articles See all "Cited by" articles. Animals Actions. Intubation, Gastrointestinal Actions. Male Actions. Rats Actions. Rats, Wistar Actions. Substances Biogenic Monoamines Actions. Metronidazole Actions. Serotonin Actions. Ethanol Actions. Hydroxyindoleacetic Acid Actions. Furazolidone Actions. Chloramphenicol Actions. Alcohol Dehydrogenase Actions. Dopamine beta-Hydroxylase Actions. Aldehyde Dehydrogenase Actions.
Acetaldehyde Actions. Quinacrine Actions. Disulfiram Actions. Dopamine Actions. Norepinephrine Actions. Homovanillic Acid Actions. Full-text links [x] Atypon. Copy Download.
Real Estate Lawyer Philippines
Amitriptyline hcl 50 mg para que sirve does amitriptyline 25 mg cause weight gain 5 stars based on reviews In such instances, dissolve in 3. If my stress levels are up i usually get one as well either under my nose or on my lips. This critical condition can be treated with Viagra PRO as well. Its time to take to contain all these cialis soft in the cialis soft soft Among the diet pills has it Losing weight is appetite suppressor nowadays but are less sodas or use artificial sweeteners instead of sugar.
Amitriptyline hcl 50 mg para que sirve does amitriptyline 25 mg cause weight gain
Medrol methylprednisolone 4 mg obat apa para que sirve el prednisolone 15 mg 5 stars based on reviews Veneers can be made to give you the natural look that you are searching for. The circumstances are hazy, keppra costco cost until Demery learns of a caustic legal dispute and a wannabe hero with a history of violence. A defendant need not make statements or testify at trial, amitriptyline hcl 4mg and that right is absolute. I'm taking better care of myself and my appearance. Prednisolone 4mg Elderly patients have a higher chance of certain side effects. Prednisolone 40 mg 0.
Medrol methylprednisolone 4 mg obat apa para que sirve el prednisolone 15 mg