Metronidazole is in It works by stopping the growth of bacteria. Antibiotics will not work for colds, flu, or Metronidazole Vaginal. Metronidazole is in a class of medications called nitroimidazole antimicrobials.

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Several pharmaceutical agents produce ethanol intolerance, which is often depicted as disulfiram-like reaction. As in the case with disulfiram, the underlying mechanism is believed to be the accumulation of acetaldehyde in the blood, due to inhibition of the hepatic aldehyde dehydrogenases. In the present study, chloramphenicol, furazolidone, metronidazole, and quinacrine, which are reported to produce a disulfiram-like reaction, as well as disulfiram, were administered to Wistar rats and the hepatic activities of alcohol and aldehyde dehydrogenases 1A1 and 2 were determined.

The expression of aldehyde dehydrogenase 2 was further assessed by Western blot analysis, while the levels of brain monoamines were also analyzed. Finally, blood acetaldehyde was evaluated after ethanol administration in rats pretreated with disulfiram, chloramphenicol, or quinacrine. The activity of aldehyde dehydrogenase 2 was inhibited by disulfiram, chloramphenicol, and furazolidone, but not by metronidazole or quinacrine.

In addition, although well known for metronidazole, quinacrine also did not increase blood acetaldehyde after ethanol administration. The protein expression of aldehyde dehydrogenase 2 was not affected at all. Interestingly, all substances used, except disulfiram, increased the levels of brain serotonin. According to our findings, metronidazole and quinacrine do not produce a typical disulfiram-like reaction, because they do not inhibit hepatic aldehyde dehydrogenase nor increase blood acetaldehyde.

Moreover, all tested agents share the common property to enhance brain serotonin, whereas a respective effect of ethanol is well established. Therefore, the ethanol intolerance produced by these agents, either aldehyde dehydrogenase is inhibited or not, could be the result of a "toxic serotonin syndrome," as in the case of the concomitant use of serotonin-active medications.

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Similar articles Differentiation of disulfiram effects on central catecholamines and hepatic ethanol metabolism. Karamanakos PN, et al. Pharmacol Toxicol. PMID: Metronidazole increases intracolonic but not peripheral blood acetaldehyde in chronic ethanol-treated rats.

Tillonen J, et al. Alcohol Clin Exp Res. Int J Toxicol. Epub Apr Jelski W, Szmitkowski M. Jelski W, et al. Clin Chim Acta. Epub May 8. PMID: Review. Susceptibility to alcohol-related liver injury. Lieber CS. Alcohol Alcohol Suppl. Show more similar articles See all similar articles. Infect Immun. Print Jan Alonzo MM, et al. J Pediatr Pharmacol Ther. Lieberman A, Curtis L. Lieberman A, et al. Drug Saf Case Rep.

Case Rep Neurol. Hennessey KM, et al. Show more "Cited by" articles See all "Cited by" articles. Animals Actions. Intubation, Gastrointestinal Actions. Male Actions. Rats Actions. Rats, Wistar Actions. Substances Biogenic Monoamines Actions. Metronidazole Actions. Serotonin Actions. Ethanol Actions. Hydroxyindoleacetic Acid Actions. Furazolidone Actions. Chloramphenicol Actions. Alcohol Dehydrogenase Actions. Dopamine beta-Hydroxylase Actions. Aldehyde Dehydrogenase Actions.

Acetaldehyde Actions. Quinacrine Actions. Disulfiram Actions. Dopamine Actions. Norepinephrine Actions. Homovanillic Acid Actions. Full-text links [x] Atypon. Copy Download.


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